![]() ![]() Though clinical trials have not shown high-dose intravenous vitamin C to produce negative side effects, it should be administered only with close monitoring and avoided in those with kidney disease and hereditary conditions like hemochromatosis and glucose 6-phosphate dehydrogenase deficiency. This is usually only seen in medically monitored settings, such as to improve the quality of life in those with advanced stage cancers or in controlled clinical studies. Vitamin C is sometimes given as an injection into a vein (intravenous) so higher amounts can directly enter the bloodstream. Ībsorption does not differ if obtaining the vitamin from food or supplements. ![]() However, adverse effects are possible with intakes greater than 3000 mg daily, including reports of diarrhea, increased formation of kidney stones in those with existing kidney disease or history of stones, increased levels of uric acid (a risk factor for gout), and increased iron absorption and overload in individuals with hemochromatosis, a hereditary condition causing excessive iron in the blood. In generally healthy adults, megadoses of vitamin C are not toxic because once the body’s tissues become saturated with vitamin C, absorption decreases and any excess amount will be excreted in urine. ![]() Studies have shown that absorption of vitamin C decreases to less than 50% when taking amounts greater than 1000 mg. The intestines have a limited ability to absorb vitamin C. Only in specific scenarios, such as under medical supervision or in controlled clinical trials, amounts higher than the UL are sometimes used. The UL for vitamin C is 2000 mg daily taking beyond this amount may promote gastrointestinal distress and diarrhea. UL: The Tolerable Upper Intake Level is the maximum daily intake unlikely to cause harmful effects on health.Smoking can deplete vitamin C levels in the body, so an additional 35 mg beyond the RDA is suggested for smokers. For pregnancy and lactation, the amount increases to 85 mg and 120 mg daily, respectively. RDA: The Recommended Dietary Allowance for adults 19 years and older is 90 mg daily for men and 75 mg for women.While megadosing on this vitamin is not uncommon, how much is an optimum amount needed to keep you healthy, and could taking too much be counterproductive? Recommended Amounts The vitamin helps make several hormones and chemical messengers used in the brain and nerves. It is needed to make collagen, a fibrous protein in connective tissue that is weaved throughout various systems in the body: nervous, immune, bone, cartilage, blood, and others. Vitamin C plays a role in controlling infections and healing wounds, and is a powerful antioxidant that can neutralize harmful free radicals. Even before its discovery in 1932, nutrition experts recognized that something in citrus fruits could prevent scurvy, a disease that killed as many as two million sailors between 15. This means that it dissolves in water and is delivered to the body’s tissues but is not well stored, so it must be taken daily through food or supplements. Vitamin C, or ascorbic acid, is a water-soluble vitamin. Is a glass of OJ or vitamin C tablets your go-to when the sniffles come? Loading up on this vitamin was a practice spurred by Linus Pauling in the 1970s, a double Nobel laureate and self-proclaimed champion of vitamin C who promoted daily megadoses (the amount in 12 to 24 oranges) as a way to prevent colds and some chronic diseases. ![]()
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